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Lipitor is used for lowering high cholesterol and triglycerides in certain patients.

Atorvastatin is generic for lipitor, with a different side effects profile which has led to a very large marketing gap in Europe where the former is not available at all. The FDA has approved statins in the U.S., but they are not being marketed widely because they do not work. It's important to be aware of the difference between U.S. FDA approval and the EU approval, as both show what is potentially known, but not yet proven, based on preclinical studies. The European approval is based on "preclinical and human data," while FDA approval in the U.S. is often limited to clinical data that includes a group of healthy volunteers. For more information, see the FDA's website on statins and the U.S. patent website. So, is it a risk to take statin for the primary prevention of myocardial infarction? Statins are not recommended for primary prevention in healthy adults. The U.S. FDA has not approved statins for primary prevention of CHD in healthy adults. The European FDA approval is only for primary prevention in those at significantly increased risk of cardiovascular events, such as those with known heart disease or cardiovascular complications, with a strong family history of premature (early stage) CHD. The results from large clinical trials are not always consistent, and the risks of statin use must be weighed against their benefits in order to determine if the combination of statins with atorvastatin could potentially reduce your cardiovascular risk. A recent systematic review and meta-analysis reported an average relative risk (RR) of 0.88 (0.74 to 1.01) for secondary prevention, with prevention involving the use of combination therapies atorvastatin with another statin; the risk increased with age, and was not affected Atorva 50 Pills 100mg $215 - $4.3 Per pill by BMI. The authors stated that this meta-analysis and its findings do not support the use of combination atorvastatin with another statin for the secondary prevention of CHD. In 2013, the Cochrane Database of Systematic Reviews published a meta-analysis on the possible benefits and harms of statins in secondary prevention coronary stroke, and the results were not consistent with the previous meta-analysis. In summary, they reported that there are not sufficient data regarding the impact of statins in secondary prevention stroke. The current cardiovascular guidelines for primary and secondary prevention are not based on any available data about their use in secondary prevention of CHD. This is why we do not recommend that you go on a statin treatment journey. Your healthcare provider will help you decide which statin combination works best for you and your particular risks benefit profile. Statin use in women Statins have been shown to reduce the risk of some cardiovascular and other serious events. One such statin, lovastatin (Mevacor), is a specific inhibitor of cholesterol biosynthesis, the main function of LDL. It is manufactured on a purified bovine genetic expression system as the purified form of lovastatin. It is not a synthetic or man-made version of lovastatin, which is why it has a lower side effect profile when given in pills, capsules, or as a suspension in liquid. Movacor has the same ability to induce LDL reduction, but in a different manner than statin; it does not affect synthesis with LDL anymore when taken as a treatment, whereas statins can have a negative impact on synthesis when taken a daily basis. Like statins, the effects of lovastatin in patients with established atherosclerosis and CHD are reversible when the drug is discontinued, regardless of duration therapy. It is well known that women on statins suffer a higher rate of cardiovascular disease than men. Because women have different LDL levels and an particle profile compared to men, statins may not be as effective against the disease and other adverse effects of the medications. risk for CHD associated with statin therapy for women may be higher than that of men. In women who have established CHD atorvastatin 80 mg coupon or severe atherosclerosis, who do not show clinically evident signs of atherosclerosis (such as fatty streaks or microvascular obstruction), statins may benefit the disease by reducing plaque formation and lowering cholesterol levels. Statins were not recommended in women because the increased risk of cardiovascular events associated with statin treatment.

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Atorvastatin 40 mg precio vs (placebo + pravastatin 40 mg precio) 20 wk: HbA1c reduction of 4.5% vs placebo and 2.2% pravastatin 40 mg precio; median HbA1c reduction was 4.1% and 2.5 percentage points, respectively. Pravastatin 40 mg precio improved lipid profile compared with pravastatin 20 mg precio. In a randomized, parallel-group trial 1,876 patients with newly diagnosed, treated, or treated non-small cell lung cancer and undergoing total hip replacement, a randomized, double-blind, placebo-controlled trial of pravastatin 20 mg/30 mg vs placebo, with a maximum tolerated Atorva 50mg $58.36 - $0.49 Per pill dose of 20 mg, compared with placebo revealed statistically significant improvements in primary and secondary endpoints, compared with placebo, after 24 weeks (RR: 0.87; 95% CI: 0.70, 1.02; P < Atorvastatin 10 mg coupon 0.0001), but did not reach statistical significance for secondary endpoints. However, when combined with the combination of pravastatin 40 mg/60 mg in combination with aspirin at doses up to 200 mg (compared with placebo), there was a statistically significant improvement in all-cause mortality (RR: 0.62; 95% CI: 0.47, 0.85) at 24 weeks. In a randomized, controlled, phase 3 trial comparing the combination of a pravastatin 20 mg/60 mg combination with daratumumab (a monoclonal anti-CD20 antibody) for recurrent or new-onset non-small cell lung cancer, compared with the combination of a pravastatin 20 mg/60 mg combo with pravastatin 80 mg, 20 canada drug pharmacy free shipping code mg/60 mg (and pravastatin 80 mg), or placebo, the combination was found to decrease the recurrence of new-onset non-small cell lung cancer compared to pravastatin 40 mg and 20 (RRs, 0.66 0.60 per 1,000 person-years of follow-up, respectively). The combination pravastatin 40 mg/60 mg and daratumumab was also shown to decrease the risk recurrence of newly diagnosed non-small cell lung cancer compared with placebo. At the end of 16-week study, a combination combined dose of pravastatin 20 mg/60 mg and daratumumab was statistically significantly better than either of two other monoclonal anti-CD20 antibodies: antibody 821 (A092) (0.69; 95% CI: 0.48, 0.91; P < 0.0001) and non-monoclonal antibody TNF-α (R0902a) (0.65; 95% CI: 0.45, 0.88; P < 0.0001) or a non-monoclonal antibody C18 (6-3R) (0.61; 95% CI: 0.38, 0.95; P < 0.0001) (Figure 2). Data from an uncontrolled, Cost of atorvastatin 20 mg large, phase 3 study in 15,066 patients with non-small cell lung cancer found statistically significantly more patients had a statistically significantly greater reduction in the recurrence rates for combination pravastatin 20 mg/60 mg with aracemide, compared the combination pravastatin 20 mg/60 mg and placebo, but this benefit was not shown in the combination pravastatin 20 mg/60 mg with daratumumab. Patients with relapsed or newly diagnosed non-small cell lung cancer who received pravastatin 40 mg and/or 60 or placebo the combination of pravast.

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Posted on September 18, 2011 by ascottlcsw

It’s time to get out in the air. You have to be selfish about
air, you know, breathe deep. Drink a lot of water too. Air
and water, food, and shelter, are essential components to life.
Relationships add that thrill to the ride. You might be longing
for that thrill or you might be involved with someone already,
looking to get that thrill back. Perhaps you’ve reached the
three year stalemate, when your partner begins to have a
certain tarnish, and has lost that golden glow they once had.
Relationships are hard work. A long term relationship needs
attention, don’t let anyone tell you otherwise. Reaching
three years is now the equivalent to the “seven year itch”
it used to take for couples to start getting tired of each
other. Now is the time you have to set the stage for the
passion that spontaneously occurred between the two
of you in the beginning of the relationship. That means
putting down your electronics, iphone, ipod, laptop, or
other assorted electronics, and look your love in the eyes.

It could be a matter of timing. Timing is essential to love.
It could be the right time, “all systems go,” but that person
isn’t perfect, mannerly enough, or beautiful, and you
count them out. How many chances do you get
when it comes to love? How many lives do you
have to live? Life is short, and you have limited
time. Many answers you will find regarding your
relationship look the same, it’s like not being able
to see the forest thru the trees. You can lose your
sense of direction, get hung up on specific problems,
and sit in a lumpish state of frustration. Not finding
your sense of timing throws you off again, it’s like
having brain freeze, and life doesn’t make sense, nor
does your partner who you have been fighting with.
Too much time spent on arguing about the little
things, leaves you hurrying to address the bigger
picture, the subjects you fear. Address fearful topics
with care, but don’t avoid them. Time will grind you
down, leaping forward would be a better risk worth
taking. Run across the field to your love.

“You have to walk carefully in the beginning of love;
the running across fields into your lover’s arms can only
come later when you’re sure they won’t laugh if you trip.”
Jonathan Carroll “Outside The Dog Museum”

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Teen Life and Pressures

Posted on September 17, 2011 by ascottlcsw
There is much to be said about surviving adolescence. What is going on in the lives of our preteens, and teens?  There are huge pressures on teens today, as in the issues of pairing up, boyfriend/girlfriend drama, drama between friends, sexting, fighting, bullying, suicide, cutting, depersonalization, and being disconnected from a community. Living in an age of technological advances has disadvantages, the practicing of social skills has changed. Now teens rely on skyping, texting, facebooking, and chatting online to have contact with others. Face-to-face socializing has decreased. As good as it is, the current school curriculum can’t address all the concerns that our youth have today. There are huge pressures, budget cuts, community and political support issues on the schools themselves. Teens today have schedules that are crammed, academics are more challenging and competitive than they used to be. Sure there are relief counselors, and support counselors on school site, but is this enough? Are the counselors themselves utilized well? One counselor is responsible for so many teens its astounding.  What about those teens who want to talk, but can’t, due to peer pressure, family issues, or overwhelming fear? The pyramid structure (the “populars” at the top, of course) of our society is still rigid, and there is a general lack of empathy running through our youth. Practicing the reduction of negative expressed emotion, identifying your feelings, becoming sensitized to your mood and its effect on others, is not valued.

Life is complicated. It isn’t as simple as saying technology gets in the way. On the more serious side, this year, there was a teen suicide that affected many young people and adults, and had ripple effects on the lives of others.  Some of those effects possibly will remain unknown to others, because it is so painful to discuss. I know this much, it is held inside those who were affected for the rest of their lives. There is a lot of bravado going on, avoidance, and denial. Many teens were those people who were affected, they needed to verbalize their confusion, sadness, and anger, and sort through the feelings they experienced. There were two other suicides in the area, three years before, the after effects of these devastating deaths seem to have gone underground. 

This is a town like many, that doesn’t know how to address the needs of those who fall between the cracks, and are floundering under the pressure that falls on their shoulders. There are teens here, struggling to find a place in the world, and some are teetering in a death defying balancing act.  Pride can get in the way of addressing what isn’t working in the community. After all, it’s a nice place to live. However, I’m sure that most teens would definitely suggest that more could be going on here in terms of activities, and finding appropriate outlets for youthful energy. A teen found dead, full of drugs, and nobody really talks about it, accidents in cars that result in death, tragedies happening before our children’s eyes.  I am seeing more teens in my practice with depression, more social anxiety, and more bipolar disorder. Yes, I understand that distress is part of our living, but what about the public discussion and exploration of these very profound traumas, and life changing events? 
Posted in teens, adolescent stress | Leave a comment